Signal Transduction by a Death Signal Peptide

Life and death of a signal peptide.

Targeted Lymphoma Cell Death by Novel Signal Transduction Modifications

CD22 is a B-cell specific membrane glyco-protein that mediates homotypic and heterotypic celladhesion; it also regulates B-cell receptor (BCR)-mediatedsignals. Monoclonal antibodies (mAb) directed at theligand binding domain of CD22 initiate CD22-mediatedsignal transduction and apoptosis in B-cell lymphomas(NHL). Amino acid analysis of the complimentary deter-mining ...

Signal transduction.

This issue of Breast Disease focuses on the subject of signal transduction and its role in the pathogenesis and progression of human breast cancer. Within the past 10 years, the explosion in our knowledge of these processes has significantly altered our understanding of breast cancer, and resulted in the first receptor-based therapies. This issue examines a variety of relevant signaling pathway...

Noisy signal amplification in ultrasensitive signal transduction.

Because intracellular processes are inherently noisy, stochastic reactions process noisy signals in cellular signal transduction. One essential feature of biological signal transduction systems is the amplification of small changes in input signals. However, small random changes in the input signals could also be amplified, and the transduction reaction can also generate noise. Here, we show th...

Cell death signal transduction and Bcl-2 function.

The mechanism by which Bcl-2 can insulate cells against multiple diverse apoptotic signals is largely undefined. How is it possible that Bcl-2, which possesses no known catalytic function, can protect against multiple cell-death signals? A proposal to address this question postulates that Bcl-2 functions at convergence points common to most cell-death signal-transduction pathways. This review a...